Providers that are interested in participating in CMMI’s recently announced Enhancing Oncology Model (EOM) will have to take on financial accountability for certain chemotherapy care for Medicare fee-for-service (FFS) patients. EOM builds on CMMI’s recently completed Oncology Care Model, with the aim of generating savings for the Medicare FFS program while enhancing the care provided to oncology patients. This article highlights key components and considerations of the new model, including changes to cancer types, risk arrangements, novel therapy adjustments, and other notable updates.